Endocrine Abstracts

Context: The immune checkpoint inhibitor (ICI) therapy is frequently used to treat advanced cancers. Autoimmune adverse events have been reported, such as endocrine side effects including frequent thyroid disorders and more rarely hypophysitis. The aim of this study was to describe retrospectively the association thyroiditis-hypophysitis.Patients and method: From 99 patients with endocrine side effects of the ImmuCare cohort, 18 patients with hypophysiti...

Background: In 2016, a prospective study conducted by our team found a prevalence of 7.7% of pheochromocytomas (Pheo) in patients with neurofibromatosis type 1 (NF1) if systematic screening including free metanephrines measurement (DMX) and abdominal imaging was performed. Half of Pheo were secreting, with 16% being symptomatic. This suggested the benefit of a systematic screening by abdominal imaging and DMX assay. The objective of this study was to evaluate the impact of sys...

Background: The increasing age of the general population represents a new challenge for endocrinologists and caregivers since it is well know that the occurrence of thyroid dysfunction increases with age. It is still controversial whether or not reference values of thyrotropin (TSH) adapted to age and sex need to be used. Herein, we aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration and follow-up during adult life in a tertia...

Objectives: Management of functional head and neck paragangliomas (HNPGLf) presents a substantial challenge due to their rarity, the lack of standardized treatment protocols, their complex neurovascular anatomical location, and the cardiovascular risks associated with catecholamine (CA) hypersecretion. This study aimed to describe the clinical characteristics of HNPGLf and their treatment outcomes.Methods: We retrospectively analyzed a cohort of HNPGLf p...